T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.
Caruso, R., Botti, E., Sarra, M., Esposito, M., Stolfi, C., Diluvio, L., et al. (2009). Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. NATURE MEDICINE, 15(9), 1013-1015 [10.1038/nm.1995].
Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis
Botti, E;Stolfi, C;Campione, E;CHIMENTI, SERGIO;PALLONE, FRANCESCO;COSTANZO, ANTONIO;MONTELEONE, GIOVANNI
2009-01-01
Abstract
T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.Questo articolo è pubblicato sotto una Licenza Licenza Creative Commons
