The authors report and discuss a patient admitted to intensive care unit (ICU) for acute respiratory failure due to upper airway obstruction caused by face and neck soft tissue infection. An oxacillin-resistant Staphyloccoccus aureus was isolated from necrotic skin lesions and from skin biopsy. The strain was susceptible in vitro to teicoplanin, but it showed resistance in vivo, despite appropriate dosage. After 6 days of full dose therapy, since the clinical course worsened, teicoplanin was interrupted and linezolid was started. In 48 hours signs of infection regressed, and the patient was discharged from the ICU after 10 days of linezolid treatment. Linezolid resulted as a rescue drug for a life-threatening infection.

Testore, G.p., Natoli, S., Fontana, C., Buonuomini, A.r., Leonardi, L., Leonardis, F. (2006). Linezolid as rescue drug: A clinical case of soft tissue infection caused by a Staphylococcus aureus strain resistant in vivo to teicoplanin. JOURNAL OF CHEMOTHERAPY, 18(4), 430-432.

Linezolid as rescue drug: A clinical case of soft tissue infection caused by a Staphylococcus aureus strain resistant in vivo to teicoplanin

NATOLI, SILVIA;FONTANA, CARLA;LEONARDIS, FRANCESCA
2006-01-01

Abstract

The authors report and discuss a patient admitted to intensive care unit (ICU) for acute respiratory failure due to upper airway obstruction caused by face and neck soft tissue infection. An oxacillin-resistant Staphyloccoccus aureus was isolated from necrotic skin lesions and from skin biopsy. The strain was susceptible in vitro to teicoplanin, but it showed resistance in vivo, despite appropriate dosage. After 6 days of full dose therapy, since the clinical course worsened, teicoplanin was interrupted and linezolid was started. In 48 hours signs of infection regressed, and the patient was discharged from the ICU after 10 days of linezolid treatment. Linezolid resulted as a rescue drug for a life-threatening infection.
2006
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/41 - ANESTESIOLOGIA
English
Con Impact Factor ISI
linezolid; soft tissue infection; teicoplanin; Staphylococcus aureus cellulites
PENETRATION; PHARMACOKINETICS
Testore, G.p., Natoli, S., Fontana, C., Buonuomini, A.r., Leonardi, L., Leonardis, F. (2006). Linezolid as rescue drug: A clinical case of soft tissue infection caused by a Staphylococcus aureus strain resistant in vivo to teicoplanin. JOURNAL OF CHEMOTHERAPY, 18(4), 430-432.
Testore, Gp; Natoli, S; Fontana, C; Buonuomini, Ar; Leonardi, L; Leonardis, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/48142
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