Five-fluorouracil (FU), mainly associated with leucovorin (L), plays an essential role in chemotherapy of colorectal carcinoma. Moreover, FU +/- L has been found to increase the expression of tumor-associated carcinoembryonic antigen (CEA), that may be an important target in therapeutic protocols of active specific immunotherapy. FU + L (FUL) are frequently combined with oxaliplatin (OXA) in advanced colon cancer patients. Thus, we investigated whether FUL in combination with OXA according to 2 different schedules may influence CEA expression in human colon cancer cells in vitro.

Prete, S., Turriziani, M., Massara, M., De Rossi, A., Correale, P., DE VECCHIS, L., et al. (2008). Combined effects of 5-fluorouracil, folinic acid and oxaliplatin on the expression of carcinoembryonic antigen in human colon cancer cells: pharmacological basis to develop an active antitumor immunochemotherapy. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 27, 5-5 [10.1186/1756-9966-27-5].

Combined effects of 5-fluorouracil, folinic acid and oxaliplatin on the expression of carcinoembryonic antigen in human colon cancer cells: pharmacological basis to develop an active antitumor immunochemotherapy

TURRIZIANI, MARIO;DE VECCHIS, LIANA;TORINO, FRANCESCO;AQUINO, ANGELO
2008-01-01

Abstract

Five-fluorouracil (FU), mainly associated with leucovorin (L), plays an essential role in chemotherapy of colorectal carcinoma. Moreover, FU +/- L has been found to increase the expression of tumor-associated carcinoembryonic antigen (CEA), that may be an important target in therapeutic protocols of active specific immunotherapy. FU + L (FUL) are frequently combined with oxaliplatin (OXA) in advanced colon cancer patients. Thus, we investigated whether FUL in combination with OXA according to 2 different schedules may influence CEA expression in human colon cancer cells in vitro.
2008
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/14 - FARMACOLOGIA
Settore MED/06 - ONCOLOGIA MEDICA
English
Con Impact Factor ISI
RNA, Messenger; Carcinoembryonic Antigen; Antineoplastic Agents; Humans; Fluorouracil; Organoplatinum Compounds; Leucovorin; Flow Cytometry; Cell Line, Tumor; Colonic Neoplasms
Prete, S., Turriziani, M., Massara, M., De Rossi, A., Correale, P., DE VECCHIS, L., et al. (2008). Combined effects of 5-fluorouracil, folinic acid and oxaliplatin on the expression of carcinoembryonic antigen in human colon cancer cells: pharmacological basis to develop an active antitumor immunochemotherapy. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 27, 5-5 [10.1186/1756-9966-27-5].
Prete, S; Turriziani, M; Massara, M; De Rossi, A; Correale, P; DE VECCHIS, L; Torino, F; Bonmassar, L; Aquino, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/48092
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