The activity of moxifloxacin was enhanced by the addition of ethionamide but not by that of cycloserine, thiacetazone, capreomycin, para-aminosalicylic acid, or linezolid in BALB/c mice infected with a strain of Mycobacterium tuberculosis resistant to isoniazid, rifampin, and six other drugs. These observations are important for the therapy of multidrug-resistant tuberculosis.

Fattorini, L., Tan, D., Iona, E., Mattei, M., Giannoni, F., Brunori, L., et al. (2003). Activities of moxifloxacin alone and in combination with other antimicrobial agents against multidrug-resistant Mycobacterium tuberculosis infection in BALB/c mice. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 47(1), 360-362 [10.1128/AAC.47.1.360-362.2003].

Activities of moxifloxacin alone and in combination with other antimicrobial agents against multidrug-resistant Mycobacterium tuberculosis infection in BALB/c mice

MATTEI, MAURIZIO;
2003-01-01

Abstract

The activity of moxifloxacin was enhanced by the addition of ethionamide but not by that of cycloserine, thiacetazone, capreomycin, para-aminosalicylic acid, or linezolid in BALB/c mice infected with a strain of Mycobacterium tuberculosis resistant to isoniazid, rifampin, and six other drugs. These observations are important for the therapy of multidrug-resistant tuberculosis.
2003
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/04 - PATOLOGIA GENERALE
English
Con Impact Factor ISI
aminosalicylic acid; antibiotic agent; capreomycin; ciprofloxacin; cycloserine; ethambutol; ethionamide; isoniazid; kanamycin; linezolid; moxifloxacin; quinoline derived antiinfective agent; rifabutin; rifampicin; rifapentine; sparfloxacin; streptomycin; thioacetazone; tuberculostatic agent; animal model; antibiotic resistance; article; bacterium isolate; colony forming unit; controlled study; experimental infection; male; minimum inhibitory concentration; mouse; multidrug resistance; Mycobacterium tuberculosis; nonhuman; priority journal; tuberculosis; Animals; Anti-Bacterial Agents; Aza Compounds; Drug Therapy, Combination; Ethionamide; Fluoroquinolones; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Quinolines; Tuberculosis, Multidrug-Resistant
Fattorini, L., Tan, D., Iona, E., Mattei, M., Giannoni, F., Brunori, L., et al. (2003). Activities of moxifloxacin alone and in combination with other antimicrobial agents against multidrug-resistant Mycobacterium tuberculosis infection in BALB/c mice. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 47(1), 360-362 [10.1128/AAC.47.1.360-362.2003].
Fattorini, L; Tan, D; Iona, E; Mattei, M; Giannoni, F; Brunori, L; Recchia, S; Orefici, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/43593
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