The efficacy of Phosphodiesterase 5 (PDE5) inhibitors to re-establish endothelial function is reduced in diabetic patients. Recent evidences suggest that therapy with PDE5 inhibitors, i.e. sildenafil, may increase the expression of nitric oxide synthase (NOS) proteins in the heart and cardiomyocytes. In this study we analyzed the effect of sildenafil on endothelial cells in insulin resistance conditions in vitro.
Mammi, C., Pastore, D., Lombardo, M., Ferrelli, F., Caprio, M., Consoli, C., et al. (2011). Sildenafil reduces insulin-resistance in human endothelial cells. PLOS ONE, 6(1), e14542-e14542 [10.1371/journal.pone.0014542].
Sildenafil reduces insulin-resistance in human endothelial cells
PASTORE, DONATELLA;TESAURO, MANFREDI;FEDERICI, MASSIMO;SBRACCIA, PAOLO;DONADEL, GIULIA;BELLIA, ALFONSO;FABBRI, ANDREA;LAURO, DAVIDE
2011-01-01
Abstract
The efficacy of Phosphodiesterase 5 (PDE5) inhibitors to re-establish endothelial function is reduced in diabetic patients. Recent evidences suggest that therapy with PDE5 inhibitors, i.e. sildenafil, may increase the expression of nitric oxide synthase (NOS) proteins in the heart and cardiomyocytes. In this study we analyzed the effect of sildenafil on endothelial cells in insulin resistance conditions in vitro.| File | Dimensione | Formato | |
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