Background: Ductal intraepitelial neoplasia (DIN) represents a spectrum of disease that may progress from usual hyperplasia to ductal carcinoma in situ (DCIS) grade 3. The aim of the study was to asses the correlation between the DIN classification and the surgical treatment including sentinel lymph node biopsy (SLNB). Patients and Methods: In this retrospective study, 229 patients with DIN had undergone conservative or radical surgical treatment and SLNB in cases of DIN1C-DIN3. Results: Breast conservative surgery was the definitive treatment in 80% of the cases. The H&E evaluation of excised sentinel nodes was negative for metastatic disease; neverthless the immunohistochemical (IHC) evaluation revealed the presence of metastatic cells in 6 patients (3.7%). Conclusion: In cases of DIN lesions SLNB is not indicated. The only reason SLNB should be considered is when there is an evidence of invasive foci at definitive histology or when radical mastectomy is proposed.

Buonomo, O.c., Orsaria, P., Contino, G., Varvaras, D., Gioia, A., Bonanno, E., et al. (2009). Pathological classification of DCIS and planning of therapeutic management. ANTICANCER RESEARCH, 29(5), 1499-1506.

Pathological classification of DCIS and planning of therapeutic management

BUONOMO, ORESTE CLAUDIO;BONANNO, ELENA;PISTOLESE, CHIARA ADRIANA;COSSU, ELSA;SCHILLACI, ORAZIO;ROSELLI, MARIO;MINEO, TOMMASO CLAUDIO;PETRELLA, GIUSEPPE
2009-01-01

Abstract

Background: Ductal intraepitelial neoplasia (DIN) represents a spectrum of disease that may progress from usual hyperplasia to ductal carcinoma in situ (DCIS) grade 3. The aim of the study was to asses the correlation between the DIN classification and the surgical treatment including sentinel lymph node biopsy (SLNB). Patients and Methods: In this retrospective study, 229 patients with DIN had undergone conservative or radical surgical treatment and SLNB in cases of DIN1C-DIN3. Results: Breast conservative surgery was the definitive treatment in 80% of the cases. The H&E evaluation of excised sentinel nodes was negative for metastatic disease; neverthless the immunohistochemical (IHC) evaluation revealed the presence of metastatic cells in 6 patients (3.7%). Conclusion: In cases of DIN lesions SLNB is not indicated. The only reason SLNB should be considered is when there is an evidence of invasive foci at definitive histology or when radical mastectomy is proposed.
2009
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/08 - ANATOMIA PATOLOGICA
Settore MED/18 - CHIRURGIA GENERALE
Settore MED/06 - ONCOLOGIA MEDICA
Settore MED/50 - SCIENZE TECNICHE MEDICHE APPLICATE
Settore MED/21 - CHIRURGIA TORACICA
English
breast cancer; ductal in situ carcinoma; lymph node; sentinel node biopsy; sentinel lymph node biopsy; humans; adult; patient care planning; breast neoplasms; middle aged; carcinoma, intraductal, noninfiltrating; immunohistochemistry; female
http://ar.iiarjournals.org/content/by/year
Buonomo, O.c., Orsaria, P., Contino, G., Varvaras, D., Gioia, A., Bonanno, E., et al. (2009). Pathological classification of DCIS and planning of therapeutic management. ANTICANCER RESEARCH, 29(5), 1499-1506.
Buonomo, Oc; Orsaria, P; Contino, G; Varvaras, D; Gioia, A; Bonanno, E; Pistolese, Ca; Cossu, E; Perretta, T; Schillaci, O; Del Monte, G; Roselli, M; Mineo, Tc; Petrella, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/38879
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