Objective: To evaluate the effectiveness for the outcomes of endometriosis-related pain and quality of life of conservative surgery plus placebo compared with conservative surgery plus hormonal suppression treatment or dietary therapy. Design: Randomized comparative trial. Setting: University hospital. Patient(s): Two hundred twenty-two consecutive women who underwent conservative pelvic surgery for symptomatic endometriosis stage III-IV (r-AFS). Intervention(s): Six months of placebo (n = 110) versus GnRH-a (tryptorelin or leuprorelin, 3.75 mg every 28 days) (n = 39) or continuous estroprogestin (ethynilestradiol, 0.03 mg plus gestoden, 0.75 mg) (n = 38) versus dietary therapy (vitamins, minerals salts, lactic ferments, fish oil) (n = 35). Main Outcome Measure(s): Painful symptoms (visual analogue scale score) and quality-of-life endometriosis-related symptoms (SF-36 score) at 12 months' follow-up. Result(s): Patients treated with postoperative hormonal suppression therapy showed less visual analogue scale scores for dysmenorrhoea than patients of the other groups. Hormonal suppression therapy and dietary supplementation were equally effective in reducing nonmenstrual pelvic pain. Surgery plus placebo showed significative decrease in dyspareunia scores. Postoperative medical and dietary therapy allowed a better quality of life than placebo. Conclusion(s): Postoperative hormonal suppression treatment or dietary therapy are more effective than surgery plus placebo to obtain relief of pain associated with endometriosis stage III-IV and improvement of quality of life. (Fertil Steril((R)) 2007;88:1541-7. (c) 2007 by American Society for Reproductive Medicine.)

Sesti, F., Pietropolli, A., Capozzolo, T., Broccoli, P., Pierangeli, S., Bollea, M.r., et al. (2007). Hormonal suppression treatment or dietary therapy versus placebo in the control of painful symptoms after conservative surgery for endometriosis stage III-IV. A randomized comparative trial. FERTILITY AND STERILITY, 88(6), 1541-1547 [10.1016/j.fertnstert.2007.01.053].

Hormonal suppression treatment or dietary therapy versus placebo in the control of painful symptoms after conservative surgery for endometriosis stage III-IV. A randomized comparative trial

SESTI, FRANCESCO;PIETROPOLLI, ADALGISA;BOLLEA, MARIA ROSA;PICCIONE, EMILIO
2007-01-01

Abstract

Objective: To evaluate the effectiveness for the outcomes of endometriosis-related pain and quality of life of conservative surgery plus placebo compared with conservative surgery plus hormonal suppression treatment or dietary therapy. Design: Randomized comparative trial. Setting: University hospital. Patient(s): Two hundred twenty-two consecutive women who underwent conservative pelvic surgery for symptomatic endometriosis stage III-IV (r-AFS). Intervention(s): Six months of placebo (n = 110) versus GnRH-a (tryptorelin or leuprorelin, 3.75 mg every 28 days) (n = 39) or continuous estroprogestin (ethynilestradiol, 0.03 mg plus gestoden, 0.75 mg) (n = 38) versus dietary therapy (vitamins, minerals salts, lactic ferments, fish oil) (n = 35). Main Outcome Measure(s): Painful symptoms (visual analogue scale score) and quality-of-life endometriosis-related symptoms (SF-36 score) at 12 months' follow-up. Result(s): Patients treated with postoperative hormonal suppression therapy showed less visual analogue scale scores for dysmenorrhoea than patients of the other groups. Hormonal suppression therapy and dietary supplementation were equally effective in reducing nonmenstrual pelvic pain. Surgery plus placebo showed significative decrease in dyspareunia scores. Postoperative medical and dietary therapy allowed a better quality of life than placebo. Conclusion(s): Postoperative hormonal suppression treatment or dietary therapy are more effective than surgery plus placebo to obtain relief of pain associated with endometriosis stage III-IV and improvement of quality of life. (Fertil Steril((R)) 2007;88:1541-7. (c) 2007 by American Society for Reproductive Medicine.)
2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/40 - GINECOLOGIA E OSTETRICIA
English
Con Impact Factor ISI
antioxidants; conservative pelvic surgery; Endometriosis-related pain; estroprogestin; GnRH analogue
Sesti, F., Pietropolli, A., Capozzolo, T., Broccoli, P., Pierangeli, S., Bollea, M.r., et al. (2007). Hormonal suppression treatment or dietary therapy versus placebo in the control of painful symptoms after conservative surgery for endometriosis stage III-IV. A randomized comparative trial. FERTILITY AND STERILITY, 88(6), 1541-1547 [10.1016/j.fertnstert.2007.01.053].
Sesti, F; Pietropolli, A; Capozzolo, T; Broccoli, P; Pierangeli, S; Bollea, Mr; Piccione, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/37752
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