Given the increasing incidence of colorectal cancer (CRC), performing new and cost-effective stool tests is of particular importance for early diagnosis and treatment. In the present review, we describe the main characteristics, and the performance of the most recently developed stool tests in the screening setting of colorectal tumoral diseases. Most of the studies reported high sensitivity both for adenomas and CRC diagnosis; less than half studies reported also high specificity with respect to stage and localization of the tumor. However, the performance of every single test was extremely variable, reaching >95% specificity for most of DNA-based markers, although lacking sensitivity even in case of invasive CRC. A new potential stool marker of colon cancer is clusterin, a protein of particular interest for its high sensitivity and positive predictive value in patients with highly aggressive CRC. (c) 2007 Elsevier Ltd. All rights reserved.

Bonanno, E., Rulli, F., Galata, G., Pucci, S., Sesti, F., Farinon, A.m., et al. (2007). Stool test for colorectal cancer screening: What is going on?. In Surgical Oncology (pp.43-45). OXFORD : ELSEVIER SCI LTD [10.1016/j.suronc.2007.10.034].

Stool test for colorectal cancer screening: What is going on?

BONANNO, ELENA;RULLI, FRANCESCO;PUCCI, SABINA;FARINON, ATTILIO MARIA;SPAGNOLI, LUIGI GIUSTO
2007-01-01

Abstract

Given the increasing incidence of colorectal cancer (CRC), performing new and cost-effective stool tests is of particular importance for early diagnosis and treatment. In the present review, we describe the main characteristics, and the performance of the most recently developed stool tests in the screening setting of colorectal tumoral diseases. Most of the studies reported high sensitivity both for adenomas and CRC diagnosis; less than half studies reported also high specificity with respect to stage and localization of the tumor. However, the performance of every single test was extremely variable, reaching >95% specificity for most of DNA-based markers, although lacking sensitivity even in case of invasive CRC. A new potential stool marker of colon cancer is clusterin, a protein of particular interest for its high sensitivity and positive predictive value in patients with highly aggressive CRC. (c) 2007 Elsevier Ltd. All rights reserved.
Conference on Colorectal Cancer Biology, Diagnosis and Therapy
Varese, ITALY
SEP 26-29, 2007
Insubria Int Summer Sch
Rilevanza internazionale
su invito
2007
Settore MED/08 - ANATOMIA PATOLOGICA
Settore MED/18 - CHIRURGIA GENERALE
English
Colorectal cancer stool test
Intervento a convegno
Bonanno, E., Rulli, F., Galata, G., Pucci, S., Sesti, F., Farinon, A.m., et al. (2007). Stool test for colorectal cancer screening: What is going on?. In Surgical Oncology (pp.43-45). OXFORD : ELSEVIER SCI LTD [10.1016/j.suronc.2007.10.034].
Bonanno, E; Rulli, F; Galata, G; Pucci, S; Sesti, F; Farinon, Am; Spagnoli, Lg
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/36568
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