Impaired insulin-mediated vasodilation might contribute to vascular damage in insulin-resistant states. Little is known about insulin regulation of nitric oxide (NO) synthesis in insulin-resistant cells. The aim of this work was to investigate insulin regulation of NO synthesis in human umbilical vein endothelial cells (HUVECs) carrying the IRS-1 gene G972R variant, known to be associated with impaired insulin activation of the PI3-kinase (PI3-K) pathway in transfected cells.

Federici, M., Pandolfi, A., De Filippis, E., Pellegrini, G., Menghini, R., Lauro, D., et al. (2004). G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells. CIRCULATION, 109(3), 399-405 [10.1161/01.CIR.0000109498.77895.6F].

G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells

FEDERICI, MASSIMO;MENGHINI, ROSSELLA;LAURO, DAVIDE;CARDELLINI, MARINA;SESTI, GIORGIO;LAURO, RENATO;
2004-01-27

Abstract

Impaired insulin-mediated vasodilation might contribute to vascular damage in insulin-resistant states. Little is known about insulin regulation of nitric oxide (NO) synthesis in insulin-resistant cells. The aim of this work was to investigate insulin regulation of NO synthesis in human umbilical vein endothelial cells (HUVECs) carrying the IRS-1 gene G972R variant, known to be associated with impaired insulin activation of the PI3-kinase (PI3-K) pathway in transfected cells.
27-gen-2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/09 - MEDICINA INTERNA
Settore M-EDF/01 - METODI E DIDATTICHE DELLE ATTIVITA' MOTORIE
English
Con Impact Factor ISI
Polymorphism, Genetic; Humans; Proto-Oncogene Proteins c-akt; Protein-Serine-Threonine Kinases; Insulin Receptor Substrate Proteins; Endothelium, Vascular; Insulin; Phosphatidylinositol 3-Kinases; RNA, Messenger; Proto-Oncogene Proteins; Gene Expression Regulation, Enzymologic; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphorylation; Phosphoproteins; Cells, Cultured; Mitogen-Activated Protein Kinases; Signal Transduction
Federici, M., Pandolfi, A., De Filippis, E., Pellegrini, G., Menghini, R., Lauro, D., et al. (2004). G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells. CIRCULATION, 109(3), 399-405 [10.1161/01.CIR.0000109498.77895.6F].
Federici, M; Pandolfi, A; De Filippis, E; Pellegrini, G; Menghini, R; Lauro, D; Cardellini, M; Romano, M; Sesti, G; Lauro, R; Consoli, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/34871
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