To better clarify the relationship between physical activity and oxidative stress, we determined the effects of a maximal test in 18 young subjects with different training levels (six professional Athletes and 12 non-agonists (NA)). Redox homeostasis (total antioxidant activity (TAS), vitamin C and glutathione (GSH)), oxidative damage (diene conjugation and hemolysis), lymphocyte cell death and repair systems (apoptosis, micronuclei and Hsp70 expression) were evaluated. We found that agonistic training led to a chronic oxidative insult (high baseline values of oxidized glutathione (GSSG), micronuclei and hemolysis). On the contrary, NA with the lowest level of training frequency showed a well balanced profile at rest, but they were more susceptible to exercise-induced variations (GSSG/GSH and diene increased values), respect to the NA with an higher level of training. As almost all the parameters employed in this study showed inter-individual variations, the GSSG/GSH ratio remains the most sensitive and reliable marker of oxidative stress, accordingly with other data just reported in the literature. © 2006 Taylor & Francis.

Pittaluga, M., Parisi, P., Sabatini, S., Ceci, R., Caporossi, D., Catani, M.v., et al. (2004). Cellular and biochemical parameters of exercise-induced oxidative stress: Relationship with training levels. In Free Radical Research (pp.607-614). ABINGDON : TAYLOR & FRANCIS LTD [10.1080/10715760600623015].

Cellular and biochemical parameters of exercise-induced oxidative stress: Relationship with training levels

CATANI, MARIA VALERIA;SAVINI, ISABELLA;AVIGLIANO, LUCIANA
2004-07-01

Abstract

To better clarify the relationship between physical activity and oxidative stress, we determined the effects of a maximal test in 18 young subjects with different training levels (six professional Athletes and 12 non-agonists (NA)). Redox homeostasis (total antioxidant activity (TAS), vitamin C and glutathione (GSH)), oxidative damage (diene conjugation and hemolysis), lymphocyte cell death and repair systems (apoptosis, micronuclei and Hsp70 expression) were evaluated. We found that agonistic training led to a chronic oxidative insult (high baseline values of oxidized glutathione (GSSG), micronuclei and hemolysis). On the contrary, NA with the lowest level of training frequency showed a well balanced profile at rest, but they were more susceptible to exercise-induced variations (GSSG/GSH and diene increased values), respect to the NA with an higher level of training. As almost all the parameters employed in this study showed inter-individual variations, the GSSG/GSH ratio remains the most sensitive and reliable marker of oxidative stress, accordingly with other data just reported in the literature. © 2006 Taylor & Francis.
9th Annual Meeting of the European-College-of-Sport-Science
Clermont Ferrand, FRANCE
JUL 03-06, 2004
Rilevanza internazionale
lug-2004
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
English
Apoptosis; DNA damage; Oxidative stress; Physical activity; Redox balance
Intervento a convegno
Pittaluga, M., Parisi, P., Sabatini, S., Ceci, R., Caporossi, D., Catani, M.v., et al. (2004). Cellular and biochemical parameters of exercise-induced oxidative stress: Relationship with training levels. In Free Radical Research (pp.607-614). ABINGDON : TAYLOR & FRANCIS LTD [10.1080/10715760600623015].
Pittaluga, M; Parisi, P; Sabatini, S; Ceci, R; Caporossi, D; Catani, Mv; Savini, I; Avigliano, L
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/31425
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 53
social impact