The DNA binding domain of the E2 master regulator from papillomaviruses is the primary effector for most the essential activities controlled by this protein. In this review we focus on the properties of the DNA binding domain of human papillomavirus strain 16 in solution, integrating structure, dynamics, folding, stability, conformational equilibria, and DNA binding mechanism. We discuss the relevance of these processes for the different biological activities, broadening the horizon for antiviral development. In addition, the particular fold of the DNA binding domain only shared with the Epstein-Barr nuclear antigen EBNA1, suggests a link between this unique architecture and the function of viral origin binding proteins of this kind. Finally, the E2 DNA binding domain proved to be an excellent model for addressing fundamental problems of DNA recognition mechanisms and folding of intertwined dimers.

de_Prat Gay, G., Gaston, K., Cicero, D.o. (2008). The papillomavirus E2 DNA binding domain. FRONTIERS IN BIOSCIENCE, 13, 6006-6021 [10.2741/3132].

The papillomavirus E2 DNA binding domain

CICERO, DANIEL OSCAR
2008-01-01

Abstract

The DNA binding domain of the E2 master regulator from papillomaviruses is the primary effector for most the essential activities controlled by this protein. In this review we focus on the properties of the DNA binding domain of human papillomavirus strain 16 in solution, integrating structure, dynamics, folding, stability, conformational equilibria, and DNA binding mechanism. We discuss the relevance of these processes for the different biological activities, broadening the horizon for antiviral development. In addition, the particular fold of the DNA binding domain only shared with the Epstein-Barr nuclear antigen EBNA1, suggests a link between this unique architecture and the function of viral origin binding proteins of this kind. Finally, the E2 DNA binding domain proved to be an excellent model for addressing fundamental problems of DNA recognition mechanisms and folding of intertwined dimers.
2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/10 - BIOCHIMICA
English
HPV; E2; DNA replication; transcription; Dna binding; anti-viral; review
16
de_Prat Gay, G., Gaston, K., Cicero, D.o. (2008). The papillomavirus E2 DNA binding domain. FRONTIERS IN BIOSCIENCE, 13, 6006-6021 [10.2741/3132].
de_Prat Gay, G; Gaston, K; Cicero, Do
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/27720
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