In this report it is shown that nitroacetic acid 1 (O2NCH2CO2H) can be conveniently used to control the pH of a water solution over time. Time-programmable sequences of the kind pH(1(high))-pH(2(low))-pH(3(high)) can be achieved, where both the extent of the initial pH jump (pH(1(high))-pH(2(low))) and the time required for the subsequent pH rising (pH(2(low))-pH(3(high))) can be predictably controlled by a judicious choice of the absolute and relative concentrations of the reagents (acid 1 and NaOH). Successive pH(1(high))-pH(2(low))-pH(3(high)) sequences can be obtained by subsequent additions of acid 1. As a proof of concept, the method is applied to control over time the pH-dependent host-guest interaction between alpha-cyclodextrin and p-aminobenzoic acid.
Del Giudice, D., Spatola, E., Valentini, M., Bombelli, C., Ercolani, G., Di Stefano, S. (2021). Time-programmable pH: decarboxylation of nitroacetic acid allows the time-controlled rising of pH to a definite value. CHEMICAL SCIENCE, 12(21), 7460-7466 [10.1039/D1SC01196K].
Time-programmable pH: decarboxylation of nitroacetic acid allows the time-controlled rising of pH to a definite value
Ercolani, Gianfranco
;
2021-01-01
Abstract
In this report it is shown that nitroacetic acid 1 (O2NCH2CO2H) can be conveniently used to control the pH of a water solution over time. Time-programmable sequences of the kind pH(1(high))-pH(2(low))-pH(3(high)) can be achieved, where both the extent of the initial pH jump (pH(1(high))-pH(2(low))) and the time required for the subsequent pH rising (pH(2(low))-pH(3(high))) can be predictably controlled by a judicious choice of the absolute and relative concentrations of the reagents (acid 1 and NaOH). Successive pH(1(high))-pH(2(low))-pH(3(high)) sequences can be obtained by subsequent additions of acid 1. As a proof of concept, the method is applied to control over time the pH-dependent host-guest interaction between alpha-cyclodextrin and p-aminobenzoic acid.File | Dimensione | Formato | |
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