AIM: Aspergillus fumigatus is the most common opportunistic fungal pathogen and causes invasive pulmonary aspergillosis (IPA), with high mortality among immunosuppressed patients. Fungistatic activity of all-trans retinoic acid (ATRA) has been recently described in vitroWe evaluated the efficacy of ATRA in vivo and its potential synergistic interaction with other antifungal drugs.
Campione, E., Gaziano, R., Doldo, E., Marino, D., Falconi, M., Iacovelli, F., et al. (2021). Antifungal effect of all-trans retinoic acid against aspergillus fumigatus in vitro and in a pulmonary aspergillosis in vivo model. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 65(3) [10.1128/AAC.01874-20].
Antifungal effect of all-trans retinoic acid against aspergillus fumigatus in vitro and in a pulmonary aspergillosis in vivo model
Campione, Elena;Gaziano, Roberta;Doldo, Elena;Falconi, Mattia;Iacovelli, Federico;Bianchi, Luca;Di Francesco, Paolo;Del Principe, Ilaria;Pistoia, Enrico Salvatore;Orlandi, Augusto
2021-01-01
Abstract
AIM: Aspergillus fumigatus is the most common opportunistic fungal pathogen and causes invasive pulmonary aspergillosis (IPA), with high mortality among immunosuppressed patients. Fungistatic activity of all-trans retinoic acid (ATRA) has been recently described in vitroWe evaluated the efficacy of ATRA in vivo and its potential synergistic interaction with other antifungal drugs.| File | Dimensione | Formato | |
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Antifungal effect of all-trans retinoic acid against Aspergillus fumigatusin vitro and in a 1pulmonary aspergillosis in vivo model.pdf
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