Specific proinflammatory and anti-inflammatory molecules could represent useful cerebrospinal fluid (CSF) biomarkers to predict the clinical course of multiple sclerosis (MS). The proinflammatory molecule interleukin (IL)-6 has been investigated in the pathophysiology of MS and has been associated in previous smaller studies to increased disability and disease activity. Here, we wanted to further address IL-6 as a possible CSF biomarker of MS by investigating its detectability in a large cohort of 534 MS patients and in 103 individuals with other non-inflammatory neurological diseases. In these newly diagnosed patients, we also explored correlations between IL-6 detectability, MS phenotypes, and disease characteristics. We found that IL-6 was more frequently detectable in the CSF of MS patients compared with their control counterparts as significant differences emerged between patients with Clinically isolated syndrome (CIS), Relapsing-remitting (RR), and secondary progressive and primary progressive MS compared to non-inflammatory controls. IL-6 was equally present in the CSF of all MS phenotypes. In RR MS patients, IL-6 detectability was found to signal clinically and/or radiologically defined disease activity, among all other clinical characteristics. Our results add further evidence that CSF proinflammatory cytokines could be useful for the identification of those MS patients who are prone to increased disease activity. In particular, IL-6 could represent an interesting prognostic biomarker of MS, as also demonstrated in other diseases where CSF IL-6 was found to identify patients with worse disease severity.

Stampanoni Bassi, M., Iezzi, E., Drulovic, J., Pekmezovic, T., Gilio, L., Furlan, R., et al. (2020). IL-6 in the Cerebrospinal Fluid Signals Disease Activity in Multiple Sclerosis. FRONTIERS IN CELLULAR NEUROSCIENCE, 14, 120 [10.3389/fncel.2020.00120].

IL-6 in the Cerebrospinal Fluid Signals Disease Activity in Multiple Sclerosis

Marfia, Girolama Alessandra;Centonze, Diego;Buttari, Fabio
2020-06-01

Abstract

Specific proinflammatory and anti-inflammatory molecules could represent useful cerebrospinal fluid (CSF) biomarkers to predict the clinical course of multiple sclerosis (MS). The proinflammatory molecule interleukin (IL)-6 has been investigated in the pathophysiology of MS and has been associated in previous smaller studies to increased disability and disease activity. Here, we wanted to further address IL-6 as a possible CSF biomarker of MS by investigating its detectability in a large cohort of 534 MS patients and in 103 individuals with other non-inflammatory neurological diseases. In these newly diagnosed patients, we also explored correlations between IL-6 detectability, MS phenotypes, and disease characteristics. We found that IL-6 was more frequently detectable in the CSF of MS patients compared with their control counterparts as significant differences emerged between patients with Clinically isolated syndrome (CIS), Relapsing-remitting (RR), and secondary progressive and primary progressive MS compared to non-inflammatory controls. IL-6 was equally present in the CSF of all MS phenotypes. In RR MS patients, IL-6 detectability was found to signal clinically and/or radiologically defined disease activity, among all other clinical characteristics. Our results add further evidence that CSF proinflammatory cytokines could be useful for the identification of those MS patients who are prone to increased disease activity. In particular, IL-6 could represent an interesting prognostic biomarker of MS, as also demonstrated in other diseases where CSF IL-6 was found to identify patients with worse disease severity.
giu-2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
MS diagnosis
MS prognosis
cerebrospinal fluid
cytokines
interleukin-6
multiple sclerosis
progressive
relapsing–remitting
Stampanoni Bassi, M., Iezzi, E., Drulovic, J., Pekmezovic, T., Gilio, L., Furlan, R., et al. (2020). IL-6 in the Cerebrospinal Fluid Signals Disease Activity in Multiple Sclerosis. FRONTIERS IN CELLULAR NEUROSCIENCE, 14, 120 [10.3389/fncel.2020.00120].
Stampanoni Bassi, M; Iezzi, E; Drulovic, J; Pekmezovic, T; Gilio, L; Furlan, R; Finardi, A; Marfia, Ga; Sica, F; Centonze, D; Buttari, F
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
il-6 in the Cerebrospinal Fluid Signals.pdf

accesso aperto

Licenza: Non specificato
Dimensione 829.24 kB
Formato Adobe PDF
829.24 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/257254
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 30
social impact