The need of innovative, multifunctional biomaterials for the partial or complete tissue replacement is the driving-force for the search of improvements of the performances of the available materials and in the formulation of new ones. Addressing the focus to vitreous substitution, we have explored the possibility of using injectable aqueous solutions of poly(vinyl alcohol), PVA, derivatives able to form hydrogels in the ocular cavity upon UV-vis irradiation with visible light. In particular, we describe the features of hydrogels from methacrylate grafted PVA, PVA-MA, in terms of structural characteristics, degradation processes, release of low- and high- molecular weight molecules, and in vitro gelation kinetics. The mechanical properties, drug delivery tests, and theology tests suggest that PVA-MA derivatives have the potential to become a useful material for vitreous substitution.

Cavalieri, F., Miano, F., D'Antona, P., Paradossi, G. (2004). Study of gelling behavior of poly(vinyl alcohol)-methacrylate for potential utilizations in tissue replacement and drug delivery. BIOMACROMOLECULES, 5(6), 2439-2446 [10.1021/bm049654g].

Study of gelling behavior of poly(vinyl alcohol)-methacrylate for potential utilizations in tissue replacement and drug delivery

CAVALIERI, FRANCESCA;PARADOSSI, GAIO
2004-01-01

Abstract

The need of innovative, multifunctional biomaterials for the partial or complete tissue replacement is the driving-force for the search of improvements of the performances of the available materials and in the formulation of new ones. Addressing the focus to vitreous substitution, we have explored the possibility of using injectable aqueous solutions of poly(vinyl alcohol), PVA, derivatives able to form hydrogels in the ocular cavity upon UV-vis irradiation with visible light. In particular, we describe the features of hydrogels from methacrylate grafted PVA, PVA-MA, in terms of structural characteristics, degradation processes, release of low- and high- molecular weight molecules, and in vitro gelation kinetics. The mechanical properties, drug delivery tests, and theology tests suggest that PVA-MA derivatives have the potential to become a useful material for vitreous substitution.
2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore CHIM/02 - CHIMICA FISICA
English
Con Impact Factor ISI
Biomaterials; Degradation; Gels; Hydrogels; Irradiation; Macromolecules; Rheology; Solutions; Driving force; Gelation kinetics; Rheology tests; Polyvinyl alcohols; biomaterial; methacrylic acid; polyvinyl alcohol; aqueous solution; article; calculation; controlled study; degradation; drug delivery system; flow kinetics; gelation; hydrogel; in vitro study; kinetics; light irradiance; mechanical stress; molecular weight; priority journal; structure analysis; tissue engineering; ultraviolet irradiation; vitreous body; Biocompatible Materials; Diffusion; Drug Delivery Systems; Gels; Hydrogel; Hydrogels; Kinetics; Light; Macromolecular Substances; Magnetic Resonance Spectroscopy; Materials Testing; Methacrylates; Polymers; Polyvinyl Alcohol; Protons; Rheology; Temperature; Time Factors; Tissue Engineering; Ultraviolet Rays; Potato virus A
Cavalieri, F., Miano, F., D'Antona, P., Paradossi, G. (2004). Study of gelling behavior of poly(vinyl alcohol)-methacrylate for potential utilizations in tissue replacement and drug delivery. BIOMACROMOLECULES, 5(6), 2439-2446 [10.1021/bm049654g].
Cavalieri, F; Miano, F; D'Antona, P; Paradossi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/24968
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