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Platelet isoprostane 8-ISO-prostaglandin F2α (8-iso-PGF2α), a proaggregating molecule, is believed to derive from nonenzymatic oxidation of arachidonic acid. We hypothesized that NADPH is implicated in isoprostane formation and platelet activation.

Pignatelli, P., Carnevale, R., Di Santo, S., Bartimoccia, S., Sanguigni, V., Lenti, L., et al. (2011). Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction. ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, 31(2), 423-434 [10.1161/ATVBAHA.110.217885].

Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction

SANGUIGNI, VALERIO;FINOCCHI, ANDREA;
2011-02-01

Abstract

Platelet isoprostane 8-ISO-prostaglandin F2α (8-iso-PGF2α), a proaggregating molecule, is believed to derive from nonenzymatic oxidation of arachidonic acid. We hypothesized that NADPH is implicated in isoprostane formation and platelet activation.
feb-2011
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
Settore MED/09 - MEDICINA INTERNA
English
Calcium; Membrane Glycoproteins; Dose-Response Relationship, Drug; Humans; Enzyme Inhibitors; NADP; Dinoprost; NG-Nitroarginine Methyl Ester; Blood Platelets; Platelet Glycoprotein GPIIb-IIIa Complex; Nitric Oxide Synthase; Aspirin; Isoprostanes; NADPH Oxidase; Adult; Case-Control Studies; Platelet Aggregation Inhibitors; Male; Deficiency Diseases
Pignatelli, P., Carnevale, R., Di Santo, S., Bartimoccia, S., Sanguigni, V., Lenti, L., et al. (2011). Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction. ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, 31(2), 423-434 [10.1161/ATVBAHA.110.217885].
Pignatelli, P; Carnevale, R; Di Santo, S; Bartimoccia, S; Sanguigni, V; Lenti, L; Finocchi, A; Mendolicchio, L; Soresina, A; Plebani, A; Violi, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/24329
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