The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis.

Pitolli, C., Wang, Y., Mancini, M., Shi, Y., Melino, G., Amelio, I. (2019). Do Mutations Turn p53 into an Oncogene?. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(24) [10.3390/ijms20246241].

Do Mutations Turn p53 into an Oncogene?

Pitolli, Consuelo;Mancini, Mara;Melino, Gennaro;Amelio, Ivano
2019-01-01

Abstract

The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis.
2019
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore BIO/11 - BIOLOGIA MOLECOLARE
English
Pitolli, C., Wang, Y., Mancini, M., Shi, Y., Melino, G., Amelio, I. (2019). Do Mutations Turn p53 into an Oncogene?. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(24) [10.3390/ijms20246241].
Pitolli, C; Wang, Y; Mancini, M; Shi, Y; Melino, G; Amelio, I
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/238209
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