Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Hernandez, Af; Green, Jb; Janmohamed, S; D'Agostino, Rb; Granger, Cb; Jones, Np; Leiter, La; Rosenberg, Ae; Sigmon, Kn; Somerville, Mc; Thorpe, Km; Mcmurray, Jjv; Del Prato, S; Del Prato, S; Mcmurray, Jjv; D'Agostino, Rb; Granger, Cb; Hernandez, Af; Janmohamed, S; Leiter, La; Califf, Rm; Holman, R; Demets, D; Riddle, M; Goodman, S; Mcguire, D; Alexander, K; Devore, A; Melloni, C; Patel, C; Kong, D; Bloomfield, G; Roe, M; Tricoci, P; Harrison, R; Lopes, R; Mathews, R; Mehta, R; Schuyler Jones, W; Vemulapalli, S; Povsic, T; Eapen, Z; Dombrowski, K; Kolls, B; Jordan, D; Ambrosy, A; Greene, S; Mandawat, A; Shavadia, J; Cooper, L; Sharma, A; Guimaraes, P; Friedman, D; Wilson, M; Endsley, P; Gentry, T; Collier, J; Perez, K; James, K; Roush, J; Pope, C; Howell, C; Johnson, M; Bailey, M; Cole, J; Akers, T; Vandyne, B; Thomas, B; Rich, J; Bartone, S; Beaulieu, G; Brown, K; Chau, T; Christian, T; Coker, R; Greene, D; Haddock, T; Jenkins, W; Haque, G; Marquess, M; Pesarchick, J; Rethaford, R; Stone, A; 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doi:10.1016/S0140-6736(18)32261-X

Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.

Hernandez, A.f., Green, J.b., Janmohamed, S., D'Agostino, R.b., Granger, C.b., Jones, N.p., et al. (2018). Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial. THE LANCET, 392(10157), 1519-1529 [10.1016/S0140-6736(18)32261-X].