Mitochondrial structural and functional changes and the autophagy pathway crosstalk under several stress conditions. However, their interplay under physiological cell death stimulation has been unclear. In our recent report, we show that during activation-induced cell death (AICD), the T-cell receptor (TCR)-dependent pathway that controls immune tolerance, autophagy is inhibited at an early stage. Further, we found that this inhibition is coupled with mitochondria fragmentation and cristae remodeling to unleash the apoptotic program. Last, we dissected the role of macroautophagy/autophagy versus mitophagy in the context of this physiological cell death, and bulk autophagy turned out to be able to remove dysfunctional and depolarized mitochondria. Our data suggest new possible approaches to modulate the immune function in the context of autoimmunity or immunotherapy.

Corrado, M., Campello, S. (2016). Autophagy inhibition and mitochondrial remodeling join forces to amplify apoptosis in activation-induced cell death. AUTOPHAGY, 12(12), 2496-2497 [10.1080/15548627.2016.1226738].

Autophagy inhibition and mitochondrial remodeling join forces to amplify apoptosis in activation-induced cell death

Campello S.
2016-01-01

Abstract

Mitochondrial structural and functional changes and the autophagy pathway crosstalk under several stress conditions. However, their interplay under physiological cell death stimulation has been unclear. In our recent report, we show that during activation-induced cell death (AICD), the T-cell receptor (TCR)-dependent pathway that controls immune tolerance, autophagy is inhibited at an early stage. Further, we found that this inhibition is coupled with mitochondria fragmentation and cristae remodeling to unleash the apoptotic program. Last, we dissected the role of macroautophagy/autophagy versus mitophagy in the context of this physiological cell death, and bulk autophagy turned out to be able to remove dysfunctional and depolarized mitochondria. Our data suggest new possible approaches to modulate the immune function in the context of autoimmunity or immunotherapy.
2016
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
Con Impact Factor ISI
AICD; T cells; apoptosis; autophagy; mitochondria; mitochondrial dynamics; Animals; Humans; Mitochondria; Models, Biological; Ubiquitin-Protein Ligases; Apoptosis; Autophagy
Corrado, M., Campello, S. (2016). Autophagy inhibition and mitochondrial remodeling join forces to amplify apoptosis in activation-induced cell death. AUTOPHAGY, 12(12), 2496-2497 [10.1080/15548627.2016.1226738].
Corrado, M; Campello, S
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
26 2016 Corrado punctum.pdf

accesso aperto

Licenza: Copyright dell'editore
Dimensione 1.17 MB
Formato Adobe PDF
1.17 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/191195
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 9
social impact