The aim of this study was to define the clinical impact of Herpes simplex virus-1 (HSV-1) DNA detection in the low respiratory tract of hospitalized patients. Forty-nine patients admitted to the University Hospital Tor Vergata, Rome, Italy, from May 2013 to June 2014, were analysed. Inclusion criteria were the presence or absence of HSV-1 DNA in clinical routine bronchoalveolar lavage (BAL) fluid specimens. Nineteen individuals were positive (cases) and 30 negative (controls) for the presence of HSV-1 DNA. The two groups were matched for age, gender and month of BAL collection. Cases and controls differed significantly according to length of stay in hospital (p=0.027), ICU transfer (p=0.02), disease severity (p=0.003), death (p=0.009), haematological and blood chemistry tests. Among cases, survivors and deceased patients differed significantly regarding ICU transfer (p=0.0001), mechanical ventilation (p=0.0048), disease severity (p=0.028) and risk of death (p=0.013). A trend towards higher HSV-1 loads was observed in the cases who died. These results suggest that detection of HSV-1 DNA in BAL fluid specimens is a marker of disease severity and poor outcome. Further prospective studies are necessary to deepen the clinical significance of HSV-1 DNA detection in the lower respiratory tract of hospitalized patients.

Pica, F., Ciotti, M., Maurici, M., Buè, C., Nardi, P., Luca', G., et al. (2017). Clinical features and outcome of hospitalized patients with HSV-1 DNA in the lower respiratory tract. NEW MICROBIOLOGICA, 40(2), 107-112.

Clinical features and outcome of hospitalized patients with HSV-1 DNA in the lower respiratory tract

PICA, FRANCESCA
;
MAURICI, MASSIMO;NARDI, PAOLO;LUCA', GABRIELLA;MORONI, GABRIELLA;ROGLIANI, PAOLA;PERNO, CARLO FEDERICO;VOLPI, ANTONIO
2017-04-01

Abstract

The aim of this study was to define the clinical impact of Herpes simplex virus-1 (HSV-1) DNA detection in the low respiratory tract of hospitalized patients. Forty-nine patients admitted to the University Hospital Tor Vergata, Rome, Italy, from May 2013 to June 2014, were analysed. Inclusion criteria were the presence or absence of HSV-1 DNA in clinical routine bronchoalveolar lavage (BAL) fluid specimens. Nineteen individuals were positive (cases) and 30 negative (controls) for the presence of HSV-1 DNA. The two groups were matched for age, gender and month of BAL collection. Cases and controls differed significantly according to length of stay in hospital (p=0.027), ICU transfer (p=0.02), disease severity (p=0.003), death (p=0.009), haematological and blood chemistry tests. Among cases, survivors and deceased patients differed significantly regarding ICU transfer (p=0.0001), mechanical ventilation (p=0.0048), disease severity (p=0.028) and risk of death (p=0.013). A trend towards higher HSV-1 loads was observed in the cases who died. These results suggest that detection of HSV-1 DNA in BAL fluid specimens is a marker of disease severity and poor outcome. Further prospective studies are necessary to deepen the clinical significance of HSV-1 DNA detection in the lower respiratory tract of hospitalized patients.
apr-2017
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
Settore MED/17 - MALATTIE INFETTIVE
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
BAL fluids; Clinical outcome; HSV-1; Hospitalized patients; Viral load
Pica, F., Ciotti, M., Maurici, M., Buè, C., Nardi, P., Luca', G., et al. (2017). Clinical features and outcome of hospitalized patients with HSV-1 DNA in the lower respiratory tract. NEW MICROBIOLOGICA, 40(2), 107-112.
Pica, F; Ciotti, M; Maurici, M; Buè, C; Nardi, P; Luca', G; Moroni, G; Rogliani, P; Perno, Cf; Volpi, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/186999
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