During HIV infection, a down-modulation of CD3ζ was found on T cells, contributing to T-cell anergy. In this work, we studied the correlation between myeloid-derived suppressor cells (MDSC) frequency and T-cell CD3ζ expression. Moreover, we investigated the mechanisms of CD3ζ decrease exploited by MDSC.
Tumino, N., Turchi, F., Meschi, S., Lalle, E., Bordoni, V., Casetti, R., et al. (2015). In HIV-positive patients, myeloid-derived suppressor cells induce T-cell anergy by suppressing CD3 expression through ELF-1 inhibition. AIDS, 29(18), 2397-2407 [10.1097/QAD.0000000000000871].
In HIV-positive patients, myeloid-derived suppressor cells induce T-cell anergy by suppressing CD3 expression through ELF-1 inhibition
TUMINO, NICOLA;LALLE, ELISABETTA;MONTESANO, CARLA;COLIZZI, VITTORIO;
2015-01-01
Abstract
During HIV infection, a down-modulation of CD3ζ was found on T cells, contributing to T-cell anergy. In this work, we studied the correlation between myeloid-derived suppressor cells (MDSC) frequency and T-cell CD3ζ expression. Moreover, we investigated the mechanisms of CD3ζ decrease exploited by MDSC.File in questo prodotto:
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