Overexpression of the gene encoding phosphoprotein enriched in astrocytes 15 (PEA15), also known as phosphoprotein enriched in diabetes (PED), causes insulin resistance and diabetes in transgenic mice and has been observed in type 2 diabetic individuals. The aim of this study was to investigate whether PEA15 overexpression occurs in individuals at high risk of diabetes and whether it is associated with specific type 2 diabetes subphenotypes.

Valentino, R., Lupoli, G., Raciti, G., Oriente, F., Farinaro, E., Della Valle, E., et al. (2006). The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes. DIABETOLOGIA, 49(12), 3058-3066 [10.1007/s00125-006-0455-5].

The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes

SESTI, GIORGIO;HRIBAL, MARTA LETIZIA;CARDELLINI, MARINA;
2006-12-01

Abstract

Overexpression of the gene encoding phosphoprotein enriched in astrocytes 15 (PEA15), also known as phosphoprotein enriched in diabetes (PED), causes insulin resistance and diabetes in transgenic mice and has been observed in type 2 diabetic individuals. The aim of this study was to investigate whether PEA15 overexpression occurs in individuals at high risk of diabetes and whether it is associated with specific type 2 diabetes subphenotypes.
dic-2006
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - ENDOCRINOLOGIA
English
Adult; Blood Glucose; DNA Primers; Diabetes Mellitus, Type 2; Family; Female; Humans; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Male; Phosphoproteins; RNA; Reverse Transcriptase Polymerase Chain Reaction; Gene Expression Regulation
Valentino, R., Lupoli, G., Raciti, G., Oriente, F., Farinaro, E., Della Valle, E., et al. (2006). The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes. DIABETOLOGIA, 49(12), 3058-3066 [10.1007/s00125-006-0455-5].
Valentino, R; Lupoli, G; Raciti, G; Oriente, F; Farinaro, E; Della Valle, E; Salomone, M; Riccardi, G; Vaccaro, O; Donnarumma, G; Sesti, G; Hribal, Ml; Cardellini, M; Miele, C; Formisano, P; Beguinot, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/175517
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