Recent studies suggest that acid phosphatase locus 1 (ACP1) could be involved in T-cell antigen receptor signaling and in immune disorders. The present study shows that the ACP1( *)C allele, which is associated with elevated enzymatic activity, is significantly more common in women with endometriosis than in healthy women, but is less common in allergic than in nonallergic subjects. These findings suggest that carriers of high activity ACP1 genotypes are more susceptible to endometriosis but less susceptible to allergic manifestations than carriers of other ACP1 genotypes.

Ammendola, M., Pietropolli, A., Saccucci, P., Piccione, E., Bottini, E., Gloria, F. (2008). Acid phosphatase locus 1 genetic polymorphism, endometriosis, and allergy. FERTILITY AND STERILITY, 90(4), 1203-1205 [10.1016/j.fertnstert.2007.10.014].

Acid phosphatase locus 1 genetic polymorphism, endometriosis, and allergy

PIETROPOLLI, ADALGISA;SACCUCCI, PATRIZIA;PICCIONE, EMILIO;BOTTINI, EGIDIO;GLORIA, FULVIA
2008-10-01

Abstract

Recent studies suggest that acid phosphatase locus 1 (ACP1) could be involved in T-cell antigen receptor signaling and in immune disorders. The present study shows that the ACP1( *)C allele, which is associated with elevated enzymatic activity, is significantly more common in women with endometriosis than in healthy women, but is less common in allergic than in nonallergic subjects. These findings suggest that carriers of high activity ACP1 genotypes are more susceptible to endometriosis but less susceptible to allergic manifestations than carriers of other ACP1 genotypes.
ott-2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/01 - STATISTICA MEDICA
English
Con Impact Factor ISI
Risk Assessment; Acid Phosphatase; Female; Polymorphism, Single Nucleotide; Risk Factors; Causality; Heterozygote; Humans; Comorbidity; Endometriosis; Incidence; Adult; Genetic Predisposition to Disease; Hypersensitivity
Ammendola, M., Pietropolli, A., Saccucci, P., Piccione, E., Bottini, E., Gloria, F. (2008). Acid phosphatase locus 1 genetic polymorphism, endometriosis, and allergy. FERTILITY AND STERILITY, 90(4), 1203-1205 [10.1016/j.fertnstert.2007.10.014].
Ammendola, M; Pietropolli, A; Saccucci, P; Piccione, E; Bottini, E; Gloria, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/17456
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