The DNA damage response (DDR) is a molecular mechanism that cells have evolved to sense DNA damage (DD) to promote DNA repair, or to lead to apoptosis, or cellular senescence if the damage is too extensive. Recent evidence indicates that microRNAs (miRs) play a critical role in the regulation of DDR. Dietary bioactive compounds through miRs may affect activity of numerous genes. Among the most studied bioactive compounds modulating expression of miRs are epi-gallocatechin-3-gallate, curcumin, resveratrol and n3-polyunsaturated fatty acids. To compare the impact of these dietary compounds on DD/DDR network modulation, we performed a literature search and an in silico analysis by the DIANA-mirPathv3 software. The in silico analysis allowed us to identify pathways shared by different miRs involved in DD/DDR vis-à-vis the specific compounds. The results demonstrate that certain miRs (e.g., -146, -21) play a central role in the interplay among DD/DDR and the bioactive compounds. Furthermore, some specific pathways, such as "fatty acids biosynthesis/metabolism", "extracellular matrix-receptor interaction" and "signaling regulating the pluripotency of stem cells", appear to be targeted by most miRs affected by the studied compounds. Since DD/DDR and these pathways are strongly related to aging and carcinogenesis, the present in silico results of our study suggest that monitoring the induction of specific miRs may provide the means to assess the antiaging and chemopreventive properties of particular dietary compounds.

Carotenuto, F., Albertini, M., Coletti, D., Vilmercati, A., Campanella, L., Darzynkiewicz, Z., et al. (2016). How diet intervention via modulation of DNA damage response through microRNAs may have an effect on cancer prevention and aging, an in silico study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17(5), 752 [10.3390/ijms17050752].

How diet intervention via modulation of DNA damage response through microRNAs may have an effect on cancer prevention and aging, an in silico study

CAROTENUTO, FELICIA;
2016-01-01

Abstract

The DNA damage response (DDR) is a molecular mechanism that cells have evolved to sense DNA damage (DD) to promote DNA repair, or to lead to apoptosis, or cellular senescence if the damage is too extensive. Recent evidence indicates that microRNAs (miRs) play a critical role in the regulation of DDR. Dietary bioactive compounds through miRs may affect activity of numerous genes. Among the most studied bioactive compounds modulating expression of miRs are epi-gallocatechin-3-gallate, curcumin, resveratrol and n3-polyunsaturated fatty acids. To compare the impact of these dietary compounds on DD/DDR network modulation, we performed a literature search and an in silico analysis by the DIANA-mirPathv3 software. The in silico analysis allowed us to identify pathways shared by different miRs involved in DD/DDR vis-à-vis the specific compounds. The results demonstrate that certain miRs (e.g., -146, -21) play a central role in the interplay among DD/DDR and the bioactive compounds. Furthermore, some specific pathways, such as "fatty acids biosynthesis/metabolism", "extracellular matrix-receptor interaction" and "signaling regulating the pluripotency of stem cells", appear to be targeted by most miRs affected by the studied compounds. Since DD/DDR and these pathways are strongly related to aging and carcinogenesis, the present in silico results of our study suggest that monitoring the induction of specific miRs may provide the means to assess the antiaging and chemopreventive properties of particular dietary compounds.
2016
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/46 - SCIENZE TECNICHE DI MEDICINA E DI LABORATORIO
English
Con Impact Factor ISI
bioactive compounds; chemoprevention; curcumin; epi-gallocatechin-3gallate; food; n3-PUFA; resveratrol; Aging; Computer Simulation; Female; Humans; Male; MicroRNAs; RNA, Neoplasm; DNA Damage; Diet; Neoplasms
Carotenuto, F., Albertini, M., Coletti, D., Vilmercati, A., Campanella, L., Darzynkiewicz, Z., et al. (2016). How diet intervention via modulation of DNA damage response through microRNAs may have an effect on cancer prevention and aging, an in silico study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17(5), 752 [10.3390/ijms17050752].
Carotenuto, F; Albertini, M; Coletti, D; Vilmercati, A; Campanella, L; Darzynkiewicz, Z; Teodori, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/173488
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