Ca(2+) is an important second messenger participating in many cellular activities; when physicochemical insults deregulate its delicate homeostasis, it acts as an intrinsic stressor, producing/increasing cell damage. Damage elicits both repair and death responses; intriguingly, in those responses Ca(2+) also participates as second messenger. This delineates a dual role for Ca(2+) in cell stress, making difficult to separate the different and multiple mechanisms required for Ca(2+)-mediated control of cell survival and apoptosis. Here we attempt to disentangle the two scenarios, examining on the one side, the events implicated in deregulated Ca(2+) toxicity and the mechanisms through which this elicits reparative or death pathways; on the other, reviewing the role of Ca(2+) as a messenger in the transduction of these same signaling events.

Ghibelli, L., Cerella, C., Diederich, M. (2010). The dual role of calcium as messenger and stressor in cell damage, death, and survival. INTERNATIONAL JOURNAL OF CELL BIOLOGY, 2010, 546163 [10.1155/2010/546163].

The dual role of calcium as messenger and stressor in cell damage, death, and survival

GHIBELLI, LINA;CERELLA, CLAUDIA;
2010-01-01

Abstract

Ca(2+) is an important second messenger participating in many cellular activities; when physicochemical insults deregulate its delicate homeostasis, it acts as an intrinsic stressor, producing/increasing cell damage. Damage elicits both repair and death responses; intriguingly, in those responses Ca(2+) also participates as second messenger. This delineates a dual role for Ca(2+) in cell stress, making difficult to separate the different and multiple mechanisms required for Ca(2+)-mediated control of cell survival and apoptosis. Here we attempt to disentangle the two scenarios, examining on the one side, the events implicated in deregulated Ca(2+) toxicity and the mechanisms through which this elicits reparative or death pathways; on the other, reviewing the role of Ca(2+) as a messenger in the transduction of these same signaling events.
2010
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/13 - BIOLOGIA APPLICATA
English
Ghibelli, L., Cerella, C., Diederich, M. (2010). The dual role of calcium as messenger and stressor in cell damage, death, and survival. INTERNATIONAL JOURNAL OF CELL BIOLOGY, 2010, 546163 [10.1155/2010/546163].
Ghibelli, L; Cerella, C; Diederich, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/170673
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