Only very few studies have investigated the influence of eosinophils on the functional progression of COPD. We aimed at retrospectively analyzing the trend of pulmonary function tests over time in patients with COPD according to two baseline blood eosinophil cell count strata (<2% [EOS-] and ≥2% [EOS+]). We used the last 9-year data present in the database of our outpatient clinic and selected only those who had two blood counts that would guarantee the stability of the value of eosinophils and serial spirometry for 4 consecutive years. The analysis of the time course of the spirometric variables analysed showed differences in FEV1 and FVC decline between the subjects of the EOS- group and those of the EOS+ group. The integrated evaluation of our results suggests that the different level of blood eosinophils in the two groups may have influenced independently the time course of the pulmonary function tests and identify two subgroups of subjects with specific disease characteristics: the hyperinflator and the rapid decliner, respectively.

Rogliani, P., Puxeddu, E., Ciaprini, C., Ora, J., Onorato, A., Pezzuto, G., et al. (2016). The Time Course of Pulmonary Function Tests in COPD Patients with Different Levels of Blood Eosinophils. BIOMED RESEARCH INTERNATIONAL, 2016 [10.1155/2016/4547953].

The Time Course of Pulmonary Function Tests in COPD Patients with Different Levels of Blood Eosinophils

ROGLIANI, PAOLA;PUXEDDU, ERMANNO;CALZETTA , LUIGINO;CAZZOLA, MARIO
2016-01-01

Abstract

Only very few studies have investigated the influence of eosinophils on the functional progression of COPD. We aimed at retrospectively analyzing the trend of pulmonary function tests over time in patients with COPD according to two baseline blood eosinophil cell count strata (<2% [EOS-] and ≥2% [EOS+]). We used the last 9-year data present in the database of our outpatient clinic and selected only those who had two blood counts that would guarantee the stability of the value of eosinophils and serial spirometry for 4 consecutive years. The analysis of the time course of the spirometric variables analysed showed differences in FEV1 and FVC decline between the subjects of the EOS- group and those of the EOS+ group. The integrated evaluation of our results suggests that the different level of blood eosinophils in the two groups may have influenced independently the time course of the pulmonary function tests and identify two subgroups of subjects with specific disease characteristics: the hyperinflator and the rapid decliner, respectively.
2016
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
English
Con Impact Factor ISI
Rogliani, P., Puxeddu, E., Ciaprini, C., Ora, J., Onorato, A., Pezzuto, G., et al. (2016). The Time Course of Pulmonary Function Tests in COPD Patients with Different Levels of Blood Eosinophils. BIOMED RESEARCH INTERNATIONAL, 2016 [10.1155/2016/4547953].
Rogliani, P; Puxeddu, E; Ciaprini, C; Ora, J; Onorato, A; Pezzuto, G; Calzetta, L; Cazzola, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/170547
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