Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is incomplete or lacking. Here, we have implemented the microattribution approach to assess the pharmacogenomic biomarkers allelic spectrum in 18 European populations, mostly from developing European countries, by analyzing 1,931 pharmacogenomics biomarkers in 231 genes. Our data show significant inter-population pharmacogenomic biomarker allele frequency differences, particularly in 7 clinically actionable pharmacogenomic biomarkers in 7 European populations, affecting drug efficacy and/or toxicity of 51 medication treatment modalities. These data also reflect on the differences observed in the prevalence of high-risk genotypes in these populations, as far as common markers in the CYP2C9, CYP2C19, CYP3A5, VKORC1, SLCO1B1 and TPMT pharmacogenes are concerned. Also, our data demonstrate notable differences in predicted genotype-based warfarin dosing among these populations. Our findings can be exploited not only to develop guidelines for medical prioritization, but most importantly to facilitate integration of pharmacogenomics and to support pre-emptive pharmacogenomic testing. This may subsequently contribute towards significant cost-savings in the overall healthcare expenditure in the participating countries, where pharmacogenomics implementation proves to be cost-effective.

Mizzi, C., Dalabira, E., Kumuthini, J., Dzimiri, N., Balogh, I., Basak, N., et al. (2016). A European spectrum of pharmacogenomic biomarkers: Implications for clinical pharmacogenomics. PLOS ONE, 11(9), 1-19 [10.1371/journal.pone.0162866].

A European spectrum of pharmacogenomic biomarkers: Implications for clinical pharmacogenomics

BORGIANI, PAOLA;NOVELLI, GIUSEPPE;
2016-09-01

Abstract

Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is incomplete or lacking. Here, we have implemented the microattribution approach to assess the pharmacogenomic biomarkers allelic spectrum in 18 European populations, mostly from developing European countries, by analyzing 1,931 pharmacogenomics biomarkers in 231 genes. Our data show significant inter-population pharmacogenomic biomarker allele frequency differences, particularly in 7 clinically actionable pharmacogenomic biomarkers in 7 European populations, affecting drug efficacy and/or toxicity of 51 medication treatment modalities. These data also reflect on the differences observed in the prevalence of high-risk genotypes in these populations, as far as common markers in the CYP2C9, CYP2C19, CYP3A5, VKORC1, SLCO1B1 and TPMT pharmacogenes are concerned. Also, our data demonstrate notable differences in predicted genotype-based warfarin dosing among these populations. Our findings can be exploited not only to develop guidelines for medical prioritization, but most importantly to facilitate integration of pharmacogenomics and to support pre-emptive pharmacogenomic testing. This may subsequently contribute towards significant cost-savings in the overall healthcare expenditure in the participating countries, where pharmacogenomics implementation proves to be cost-effective.
set-2016
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/03 - GENETICA MEDICA
English
Con Impact Factor ISI
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162866
Mizzi, C., Dalabira, E., Kumuthini, J., Dzimiri, N., Balogh, I., Basak, N., et al. (2016). A European spectrum of pharmacogenomic biomarkers: Implications for clinical pharmacogenomics. PLOS ONE, 11(9), 1-19 [10.1371/journal.pone.0162866].
Mizzi, C; Dalabira, E; Kumuthini, J; Dzimiri, N; Balogh, I; Basak, N; Bohm, R; Borg, J; Borgiani, P; Bozina, N; Bruckmueller, H; Burzynska, B; Carracedo, A; Cascorbi, I; Deltas, C; Dolzan, V; Fenech, A; Grech, G; Kasiulevicius, V; Kadasi, L; Kucinskas, V; Khusnutdinova, E; Loukas, Y; Macek, M; Makukh, H; Mathijssen, R; Mitropoulos, K; Mitropoulou, C; Novelli, G; Papantoni, I; Pavlovic, S; Saglio, G; Setric, J; Stojiljkovic, M; Stubbs, A; Squassina, A; Torres, M; Turnovec, M; Van Schaik, R; Voskarides, K; Wakil, S; Werk, A; Zompo, M; Zukic, B; Katsila, T; Lee, M; Motsinger Rief, A; Leod, H; Van Der Spek, P; Patrinos, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/167757
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