Formalin-fixed, paraffin-embedded cervical tissues from 106 patients which exhibited a colposcopically atypical transformation zone, were examined for the presence of HPV DNA by in situ hybridization using biotin-labeled HPV 6/11 and 16/18 DNA probes. From the comparative study between histologic, cytologic, colposcopic findings and virologic results it is confirmed that HPV 6/11 DNA is detected more frequently in the less severe lesions, whereas HPV 16/18 DNA is predominantly found in the most severe dysplastic lesions.
Pasetto, N., Piccione, E., Mantenuto, L., Sesti, F. (1991). Cytohistology, colposcopy and in situ hybridization in cervical preneoplastic lesions: a correlative study. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 35(4), 323-6.
Cytohistology, colposcopy and in situ hybridization in cervical preneoplastic lesions: a correlative study
PICCIONE, EMILIO;SESTI, FRANCESCO
1991-08-01
Abstract
Formalin-fixed, paraffin-embedded cervical tissues from 106 patients which exhibited a colposcopically atypical transformation zone, were examined for the presence of HPV DNA by in situ hybridization using biotin-labeled HPV 6/11 and 16/18 DNA probes. From the comparative study between histologic, cytologic, colposcopic findings and virologic results it is confirmed that HPV 6/11 DNA is detected more frequently in the less severe lesions, whereas HPV 16/18 DNA is predominantly found in the most severe dysplastic lesions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
