Recent studies indicate that angiogenesis is important in the pathogenesis of acute myeloid leukemias (AMLs). Among the various AMLs, the bone marrow angiogenetic response is particularly pronounced in acute promyelocytic leukemia (APL). However, the molecular mechanisms responsible for this angiogenetic response are largely unknown. In the present study, we have explored the role of HHEX, a homeodomain transcription factor, as a possible mediator of the pro-angiogenetic response observed in APL. This transcription factor seems to represent an ideal candidate for this biologic function because it is targeted by PML-RARα, is capable of interaction with PML and PML-RARα, and acts as a regulator of the angiogenetic response.

Saulle, E., Petronelli, A., Pelosi, E., Coppotelli, E., Pasquini, L., Ilari, R., et al. (2016). PML-RAR alpha induces the downmodulation of HHEX: A key event responsible for the induction of an angiogenetic response. JOURNAL OF HEMATOLOGY & ONCOLOGY, 9(1), 33 [10.1186/s13045-016-0262-5].

PML-RAR alpha induces the downmodulation of HHEX: A key event responsible for the induction of an angiogenetic response

PASQUINI, LUCA;LO COCO, FRANCESCO;
2016-04-07

Abstract

Recent studies indicate that angiogenesis is important in the pathogenesis of acute myeloid leukemias (AMLs). Among the various AMLs, the bone marrow angiogenetic response is particularly pronounced in acute promyelocytic leukemia (APL). However, the molecular mechanisms responsible for this angiogenetic response are largely unknown. In the present study, we have explored the role of HHEX, a homeodomain transcription factor, as a possible mediator of the pro-angiogenetic response observed in APL. This transcription factor seems to represent an ideal candidate for this biologic function because it is targeted by PML-RARα, is capable of interaction with PML and PML-RARα, and acts as a regulator of the angiogenetic response.
7-apr-2016
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Saulle, E., Petronelli, A., Pelosi, E., Coppotelli, E., Pasquini, L., Ilari, R., et al. (2016). PML-RAR alpha induces the downmodulation of HHEX: A key event responsible for the induction of an angiogenetic response. JOURNAL OF HEMATOLOGY & ONCOLOGY, 9(1), 33 [10.1186/s13045-016-0262-5].
Saulle, E; Petronelli, A; Pelosi, E; Coppotelli, E; Pasquini, L; Ilari, R; LO COCO, F; Testa, U
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/160439
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