The injection of desmethylimipramine (DMI) twice daily for 3 weeks reduced the density of beta-adrenergic receptor recognition sites located in crude synaptic membranes prepared from the cortex and hippocampus and attenuated the stimulation of the membrane-bound adenylate cyclase by isoproterenol. Both actions were abolished if prior to treatment with desmethylimipramine the serotonergic axons were destroyed by an intraventricular injection of 5,7-dihydroxytryptamine. These results show that the down-regulation of beta-adrenergic receptors elicited by repeated injections of desmethylimipramine occurs only if the serotonergic axons are intact.

Brunello, N., Barbaccia, M.l., Chuang, D., Costa, E. (1982). Down-regulation of beta-adrenergic receptors following repeated injections of desmethylimipramine: permissive role of serotonergic axons. NEUROPHARMACOLOGY, 21(11), 1145-1149.

Down-regulation of beta-adrenergic receptors following repeated injections of desmethylimipramine: permissive role of serotonergic axons

BARBACCIA, MARIA LUISA;
1982-11-01

Abstract

The injection of desmethylimipramine (DMI) twice daily for 3 weeks reduced the density of beta-adrenergic receptor recognition sites located in crude synaptic membranes prepared from the cortex and hippocampus and attenuated the stimulation of the membrane-bound adenylate cyclase by isoproterenol. Both actions were abolished if prior to treatment with desmethylimipramine the serotonergic axons were destroyed by an intraventricular injection of 5,7-dihydroxytryptamine. These results show that the down-regulation of beta-adrenergic receptors elicited by repeated injections of desmethylimipramine occurs only if the serotonergic axons are intact.
nov-1982
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Axons; Hippocampus; Male; 5,7-Dihydroxytryptamine; Isoproterenol; Desipramine; Receptors, Adrenergic; Adenylate Cyclase; Antidepressive Agents; Rats; Animals; Serotonin; Cerebral Cortex; Rats, Inbred Strains; Receptors, Adrenergic, beta
Brunello, N., Barbaccia, M.l., Chuang, D., Costa, E. (1982). Down-regulation of beta-adrenergic receptors following repeated injections of desmethylimipramine: permissive role of serotonergic axons. NEUROPHARMACOLOGY, 21(11), 1145-1149.
Brunello, N; Barbaccia, Ml; Chuang, D; Costa, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/15014
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