Malignant pleural mesothelioma(MM), a rare tumor characterized by high local invasiveness and low metastatic efficiency, is poorly responsive to current therapeutic approaches. The aim of the present study was to evaluate the cytotoxic efficacy of the hybrid polar compound hexamethylene bisacetamide(HMBA), either as a single agent or in combination with the anthracycline doxorubicin (DOX), against MM cells.

Palumbo, C., ALBONICI BOVE, L., Bei, R., Bocci, C., Scarpa, S., DI NARDO, P., et al. (2004). HMBA induces cell death and potentiates doxorubicin toxicity in malignant mesothelioma cells, 54(5), 398-406 [10.1007/s00280-004-0838-6].

HMBA induces cell death and potentiates doxorubicin toxicity in malignant mesothelioma cells

PALUMBO, CAMILLA;ALBONICI BOVE, LOREDANA;BEI, ROBERTO;DI NARDO, PAOLO;MODESTI, ANDREA
2004-11-01

Abstract

Malignant pleural mesothelioma(MM), a rare tumor characterized by high local invasiveness and low metastatic efficiency, is poorly responsive to current therapeutic approaches. The aim of the present study was to evaluate the cytotoxic efficacy of the hybrid polar compound hexamethylene bisacetamide(HMBA), either as a single agent or in combination with the anthracycline doxorubicin (DOX), against MM cells.
nov-2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/04 - PATOLOGIA GENERALE
English
cell line, tumor; cell survival; antineoplastic agents; mesothelioma; drug synergism; DNA primers; cell death; RNA, neoplasm; dose-response relationship, drug; doxorubicin; humans; acetamides
Palumbo, C., ALBONICI BOVE, L., Bei, R., Bocci, C., Scarpa, S., DI NARDO, P., et al. (2004). HMBA induces cell death and potentiates doxorubicin toxicity in malignant mesothelioma cells, 54(5), 398-406 [10.1007/s00280-004-0838-6].
Palumbo, C; ALBONICI BOVE, L; Bei, R; Bocci, C; Scarpa, S; DI NARDO, P; Modesti, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/14896
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