Antioxidant therapy is the novel frontier to prevent and treat an impressive series of severe human diseases, and the search for adequate antioxidant drugs is fervent. Cerium oxide nanoparticles (nanoceria) are redox-active owing to the coexistence of Ce3þ and Ce4þ oxidation states and to the fact that Ce3þ defects, and the compensating oxygen vacancies, are more abundant at the surface. Nanoceria particles exert outstanding antioxidant effects in vivo acting as well-tolerated anti-age and anti-inflammatory agents, potentially being innovative therapeutic tools. However, the biological antioxidant mechanisms are still unclear. Here, the analysis on two leukocyte cell lines undergoing apoptosis via redox-dependent or independent mechanisms revealed that the intracellular antioxidant effect is the direct cause of the anti-apoptotic and prosurvival effects of nanoceria. Doping with increasing concentrations of Sm3þ, which progressively decreased Ce3þ without affecting oxygen vacancies, blunted these effects, demonstrating that Ce3þ/Ce4þ redox reactions are responsible for the outstanding biological properties of nanoceria.
Celardo, I., DE NICOLA, M., Mandoli, C., Pedersen, J.z., Traversa, E., Ghibelli, L. (2011). Ce3+ ions determine redox-dependent anti-apoptotic effect of cerium oxide nanoparticles. ACS NANO, 5(6), 4537-4549 [10.1021/nn200126a].
Ce3+ ions determine redox-dependent anti-apoptotic effect of cerium oxide nanoparticles.
DE NICOLA, MILENA;PEDERSEN, JENS ZACHO;TRAVERSA, ENRICO;GHIBELLI, LINA
2011-01-01
Abstract
Antioxidant therapy is the novel frontier to prevent and treat an impressive series of severe human diseases, and the search for adequate antioxidant drugs is fervent. Cerium oxide nanoparticles (nanoceria) are redox-active owing to the coexistence of Ce3þ and Ce4þ oxidation states and to the fact that Ce3þ defects, and the compensating oxygen vacancies, are more abundant at the surface. Nanoceria particles exert outstanding antioxidant effects in vivo acting as well-tolerated anti-age and anti-inflammatory agents, potentially being innovative therapeutic tools. However, the biological antioxidant mechanisms are still unclear. Here, the analysis on two leukocyte cell lines undergoing apoptosis via redox-dependent or independent mechanisms revealed that the intracellular antioxidant effect is the direct cause of the anti-apoptotic and prosurvival effects of nanoceria. Doping with increasing concentrations of Sm3þ, which progressively decreased Ce3þ without affecting oxygen vacancies, blunted these effects, demonstrating that Ce3þ/Ce4þ redox reactions are responsible for the outstanding biological properties of nanoceria.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
