Lymph node involvement in adenocarcinoma of the esophagogastric junction (EGJ) is similar to that of gastric cancer. The impact on survival of the number and site of lymph nodes involved in a subgroup of patients undergone surgery for adenocarcinoma of EGJ is reported. Sixty-four patients undergone transthoracic esophagectomy with two-field lymphadenectomy for adenocarcinoma of the EGJ were retrospectively assessed. Five-year survival according to AJCC gastric cancer nodal classification and central node invasion was evaluated. In N0 patients survival was assessed in relation to the number of lymph nodes removed. Five-year survival was 72% in N0, 46% in N1 and 0% in N2 and N3 group. Intergroup differences were statistically significant (P<0.05) except between N2 and N3 groups. Overall survival was different depending on the infiltration of distal or proximal site nodes, 23% vs. 58% (P<0.05); in N0 patients it was related to the number of lymph nodes removed (83% >15 vs. 57% <15, P<0.05). Classification of lymph node involvement in adenocarcinoma of the EGJ by gastric cancer criteria is adequate for prognostic purposes. The involvement of distal nodes in all cases and the removal of <15 nodes in N0 group resulted as independent negative predictive factors.

Jelpo, B., Sanchez Pernaute, A., Elia, S., Buonomo, O.c., Diez Valladares, L., Perez Aguirre, E., et al. (2010). Impact of number and site of lymph node invasion on survival of adenocarcinoma of esophagogastric junction. INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 10(5), 704-708 [10.1510/icvts.2009.222778].

Impact of number and site of lymph node invasion on survival of adenocarcinoma of esophagogastric junction

ELIA, STEFANO;BUONOMO, ORESTE CLAUDIO;PETRELLA, GIUSEPPE;
2010-01-01

Abstract

Lymph node involvement in adenocarcinoma of the esophagogastric junction (EGJ) is similar to that of gastric cancer. The impact on survival of the number and site of lymph nodes involved in a subgroup of patients undergone surgery for adenocarcinoma of EGJ is reported. Sixty-four patients undergone transthoracic esophagectomy with two-field lymphadenectomy for adenocarcinoma of the EGJ were retrospectively assessed. Five-year survival according to AJCC gastric cancer nodal classification and central node invasion was evaluated. In N0 patients survival was assessed in relation to the number of lymph nodes removed. Five-year survival was 72% in N0, 46% in N1 and 0% in N2 and N3 group. Intergroup differences were statistically significant (P<0.05) except between N2 and N3 groups. Overall survival was different depending on the infiltration of distal or proximal site nodes, 23% vs. 58% (P<0.05); in N0 patients it was related to the number of lymph nodes removed (83% >15 vs. 57% <15, P<0.05). Classification of lymph node involvement in adenocarcinoma of the EGJ by gastric cancer criteria is adequate for prognostic purposes. The involvement of distal nodes in all cases and the removal of <15 nodes in N0 group resulted as independent negative predictive factors.
2010
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/21 - CHIRURGIA TORACICA
English
Con Impact Factor ISI
Probability; Disease-Free Survival; Lymphatic Metastasis; Humans; Esophageal Neoplasms; Retrospective Studies; Aged; Risk Assessment; Esophagectomy; Aged, 80 and over; Adult; Treatment Outcome; Male; Survival Analysis; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Kaplan-Meier Estimate; Cohort Studies; Esophagogastric Junction; Middle Aged; Lymph Node Excision; Adenocarcinoma; Lymph Nodes; Female; Proportional Hazards Models
Jelpo, B., Sanchez Pernaute, A., Elia, S., Buonomo, O.c., Diez Valladares, L., Perez Aguirre, E., et al. (2010). Impact of number and site of lymph node invasion on survival of adenocarcinoma of esophagogastric junction. INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 10(5), 704-708 [10.1510/icvts.2009.222778].
Jelpo, B; Sanchez Pernaute, A; Elia, S; Buonomo, Oc; Diez Valladares, L; Perez Aguirre, E; Petrella, G; Torres Garcia, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/14540
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