Relationships and Responsibilities of Software Experimentation.

The ESE research has dependence relationships with Ethical control, Good Laboratory Practices, and related Guidelines. In other fields there are many types of experiments, to conduct orderly (in case of success only!) E0 acts on things, “in-vitro”; experimenters are the only humans allowed to come in contact; ESE scientists should simulate their experiment processes before involving volunteers. E1 acts on primary animals; seems not applicable for ESE experiments. E2 acts on formally informed human volunteers performing as subjects. En>2 act on dependent humans: the lower is n the greater is the level of dependency of the involved subjects. Based on the ESE practices, to the best or our knowledge, ESE experiments usually skip the stages E0, and still limit to enact (part of) E2, which is a quite frustrating fact that we should work to remove.