PURPOSE: The aim of this study was to determine the accuracy of elastosonography in the differential diagnosis of thyroid nodules using a qualitative [evaluation of the stiffness score (SS)] and quantitative assessment [evaluation of the strain ratio (SR)]. MATERIALS AND METHODS: In our single-centre retrospective study, 368 patients were enroled between December 2010 and March 2012 (134 men, 234 women, mean age 56.1 ± 14.2) with a diagnosis of thyroid nodules, who underwent conventional ultrasonographic and elastosonographic evaluation. The SS and SR were assessed and the results were expressed in terms of sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). The nodules were subjected to needle aspiration. RESULTS: Forty-four nodules were malignant (TIR ≥ 3) and 324 benign on cytological analysis. Considering a cut-off of SS > 2, we had 91% sensitivity, 68% specificity, 27% PPV and 98% NPV. Considering a cut-off of SR ≥ 3.28, we had 81.8% sensitivity, 82.7% specificity, 39.1% PPV and 97.1% NPV. CONCLUSIONS: The SR calculation did not provide additional data to the SS, which remains the elastosonography benchmark. It will be necessary to validate these preliminary data by larger prospective randomised trials.

Guazzaroni, M., Spinelli, A., Coco, I., DEL GIUDICE, C., Girardi, V., Simonetti, G. (2014). Value of strain-ratio on thyroid real-time sonoelastography. LA RADIOLOGIA MEDICA, 119(3), 149-155 [10.1007/s11547-013-0320-9].

Value of strain-ratio on thyroid real-time sonoelastography

GUAZZARONI, MANLIO;SPINELLI, ALESSIO;DEL GIUDICE, COSTANTINO;SIMONETTI, GIOVANNI MARIA EGISTO
2014-01-01

Abstract

PURPOSE: The aim of this study was to determine the accuracy of elastosonography in the differential diagnosis of thyroid nodules using a qualitative [evaluation of the stiffness score (SS)] and quantitative assessment [evaluation of the strain ratio (SR)]. MATERIALS AND METHODS: In our single-centre retrospective study, 368 patients were enroled between December 2010 and March 2012 (134 men, 234 women, mean age 56.1 ± 14.2) with a diagnosis of thyroid nodules, who underwent conventional ultrasonographic and elastosonographic evaluation. The SS and SR were assessed and the results were expressed in terms of sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). The nodules were subjected to needle aspiration. RESULTS: Forty-four nodules were malignant (TIR ≥ 3) and 324 benign on cytological analysis. Considering a cut-off of SS > 2, we had 91% sensitivity, 68% specificity, 27% PPV and 98% NPV. Considering a cut-off of SR ≥ 3.28, we had 81.8% sensitivity, 82.7% specificity, 39.1% PPV and 97.1% NPV. CONCLUSIONS: The SR calculation did not provide additional data to the SS, which remains the elastosonography benchmark. It will be necessary to validate these preliminary data by larger prospective randomised trials.
2014
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
English
Con Impact Factor ISI
ultrasonography; thyroid nodules; elastosonography
Guazzaroni, M., Spinelli, A., Coco, I., DEL GIUDICE, C., Girardi, V., Simonetti, G. (2014). Value of strain-ratio on thyroid real-time sonoelastography. LA RADIOLOGIA MEDICA, 119(3), 149-155 [10.1007/s11547-013-0320-9].
Guazzaroni, M; Spinelli, A; Coco, I; DEL GIUDICE, C; Girardi, V; Simonetti, Gme
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
Guazzaroni-2014-Value of strain-ratio on thyro.pdf

solo utenti autorizzati

Descrizione: Aricolo principale
Licenza: Copyright dell'editore
Dimensione 713.32 kB
Formato Adobe PDF
713.32 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/134537
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 19
social impact