Interleukin (IL)-25, a Th2-related factor, inhibits the synthesis of inflammatory cytokines by macrophages and attenuates experimental colitis in mice. The mechanism underlying the counterregulatory effect of IL-25, however, remains unknown. Since Th2-cytokines can abrogate inflammatory pathways by inducing alternatively activated macrophages (AAMs), we evaluated whether AAMs are involved in the IL-25-mediated anticolitic effect.

Rizzo, A., Monteleone, I., Fina, D., Stolfi, C., Caruso, R., Fantini, M.c., et al. (2012). Inhibition of colitis by IL-25 associates with induction of alternatively activated macrophages. INFLAMMATORY BOWEL DISEASES, 18(3), 449-459 [10.1002/ibd.21799].

Inhibition of colitis by IL-25 associates with induction of alternatively activated macrophages

RIZZO, ANGELAMARIA;MONTELEONE, IVAN;FINA, DANIELE;STOLFI, CARMINE;CARUSO, ROBERTA;FANTINI, MASSIMO CLAUDIO;FRANZE', ELEONORA;PALLONE, FRANCESCO;MONTELEONE, GIOVANNI
2012-01-01

Abstract

Interleukin (IL)-25, a Th2-related factor, inhibits the synthesis of inflammatory cytokines by macrophages and attenuates experimental colitis in mice. The mechanism underlying the counterregulatory effect of IL-25, however, remains unknown. Since Th2-cytokines can abrogate inflammatory pathways by inducing alternatively activated macrophages (AAMs), we evaluated whether AAMs are involved in the IL-25-mediated anticolitic effect.
2012
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - GASTROENTEROLOGIA
English
Con Impact Factor ISI
Analysis of Variance; Animals; Antibodies, Neutralizing; Antigens, Differentiation; Arginase; Cell Count; Colitis; Gene Expression; Intercellular Signaling Peptides and Proteins; Interleukin-13; Interleukin-17; Interleukin-4; Intestinal Mucosa; Lectins; Macrophages, Peritoneal; Mice; Statistics, Nonparametric; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; beta-N-Acetylhexosaminidases; Macrophage Activation
Rizzo, A., Monteleone, I., Fina, D., Stolfi, C., Caruso, R., Fantini, M.c., et al. (2012). Inhibition of colitis by IL-25 associates with induction of alternatively activated macrophages. INFLAMMATORY BOWEL DISEASES, 18(3), 449-459 [10.1002/ibd.21799].
Rizzo, A; Monteleone, I; Fina, D; Stolfi, C; Caruso, R; Fantini, Mc; Franze', E; Schwendener, R; Pallone, F; Monteleone, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/130426
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