p53 family members, p63 and p73, play a role in controlling early stage of myogenic differentiation. We demonstrated that TAp63gamma, unlike the other p53 family members, is markedly up-regulated during myogenic differentiation in murine C2C7 cell line. We also found that myotubes formation was inhibited upon TAp63gamma knock-down, as also indicated by atrophyic myotubes and reduction of myoblasts fusion index. Analysis of TAp63gamma-dependend transcripts identified several target genes involved in skeletal muscle contractility energy metabolism, myogenesis and skeletal muscle autocrine signaling. These results indicate that TAp63gamma is a late marker of myogenic differentiation and, by controlling different sub-sets of target genes, it possibly contributes to muscle growth, remodeling, functional differentiation and tissue homeostasis.

Cefalu, S., Lena, A.m., Vojtesek, B., Musaro, A., Rossi, A., Melino, G., et al. (2015). Tap63gamma is required for the late stages of myogenesis. CELL CYCLE, 14(6), 894-901 [10.4161/15384101.2014.988021].

Tap63gamma is required for the late stages of myogenesis

LENA, ANNA MARIA;ROSSI, ANTONELLO;MELINO, GENNARO;CANDI, ELEONORA
2015-01-01

Abstract

p53 family members, p63 and p73, play a role in controlling early stage of myogenic differentiation. We demonstrated that TAp63gamma, unlike the other p53 family members, is markedly up-regulated during myogenic differentiation in murine C2C7 cell line. We also found that myotubes formation was inhibited upon TAp63gamma knock-down, as also indicated by atrophyic myotubes and reduction of myoblasts fusion index. Analysis of TAp63gamma-dependend transcripts identified several target genes involved in skeletal muscle contractility energy metabolism, myogenesis and skeletal muscle autocrine signaling. These results indicate that TAp63gamma is a late marker of myogenic differentiation and, by controlling different sub-sets of target genes, it possibly contributes to muscle growth, remodeling, functional differentiation and tissue homeostasis.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/11 - BIOLOGIA MOLECOLARE
English
MHC, myosin heavy chain; MRFs, myogenic regulatory factors; Rb, retinoblastoma protein; differentiation; muscle contractility; myogenesis; p53; p63
Cefalu, S., Lena, A.m., Vojtesek, B., Musaro, A., Rossi, A., Melino, G., et al. (2015). Tap63gamma is required for the late stages of myogenesis. CELL CYCLE, 14(6), 894-901 [10.4161/15384101.2014.988021].
Cefalu, S; Lena, Am; Vojtesek, B; Musaro, A; Rossi, A; Melino, G; Candi, E
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/128096
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 15
social impact