Type 2 diabetes mellitus (T2DM) and essential hypertension are often associated, and retrospective data analyses suggest an association between lower blood pressure (BP) values and lower cardiovascular (CV) risk in patients with T2DM. However, the most recent intervention trials fail to demonstrate a further CV risk reduction, for BP levels <130/80 mm Hg, when compared to levels <140/90 mm Hg. Moreover, a J-shaped, rather than a linear, relationship of BP reduction with incident CV events has been strongly suggested. We here debate the main available evidences for and against the concept of 'the lower the better', in the light of the main intervention trials and meta-analyses, with a particular emphasis on the targets to be pursued in elderly patients. Finally, the most recent guidelines of the scientific societies are critically discussed.

Frontoni, S., Solini, A., Fioretto, P., Natali, A., Zuccala, A., Cosentino, F., et al. (2014). The ideal blood pressure target to prevent cardiovascular disease in type 2 diabetes: A neutral viewpoint. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 24(6), 577-584 [10.1016/j.numecd.2014.01.004].

The ideal blood pressure target to prevent cardiovascular disease in type 2 diabetes: A neutral viewpoint

FRONTONI, SIMONA;
2014-01-01

Abstract

Type 2 diabetes mellitus (T2DM) and essential hypertension are often associated, and retrospective data analyses suggest an association between lower blood pressure (BP) values and lower cardiovascular (CV) risk in patients with T2DM. However, the most recent intervention trials fail to demonstrate a further CV risk reduction, for BP levels <130/80 mm Hg, when compared to levels <140/90 mm Hg. Moreover, a J-shaped, rather than a linear, relationship of BP reduction with incident CV events has been strongly suggested. We here debate the main available evidences for and against the concept of 'the lower the better', in the light of the main intervention trials and meta-analyses, with a particular emphasis on the targets to be pursued in elderly patients. Finally, the most recent guidelines of the scientific societies are critically discussed.
2014
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - ENDOCRINOLOGIA
English
Con Impact Factor ISI
Anti-hypertensive treatment; Blood pressure target; Elderly; J-shaped curve; Type 2 diabetes; Age Factors; Aged; Aged, 80 and over; Antihypertensive Agents; Biological Markers; Blood Pressure; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Cardiomyopathies; Drug Monitoring; Humans; Hypertension; Individualized Medicine; International Agencies; Middle Aged; Risk Factors; Societies, Medical; Societies, Scientific; Voluntary Health Agencies; Evidence-Based Medicine; Practice Guidelines as Topic
Frontoni, S., Solini, A., Fioretto, P., Natali, A., Zuccala, A., Cosentino, F., et al. (2014). The ideal blood pressure target to prevent cardiovascular disease in type 2 diabetes: A neutral viewpoint. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 24(6), 577-584 [10.1016/j.numecd.2014.01.004].
Frontoni, S; Solini, A; Fioretto, P; Natali, A; Zuccala, A; Cosentino, F; Penno, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/126790
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