Epithelial-to-mesenchymal transition (EMT) and the reverse mesenchymal-to-epithelial transition (MET) are manifestations of cellular plasticity that imply a dynamic and profound gene expression reprogramming. While a major epigenetic code controlling the coordinated regulation of a whole transcriptional profile is guaranteed by DNA methylation, DNA methyltransferase (DNMT) activities in EMT/MET dynamics are still largely unexplored. Here, we investigated the molecular mechanisms directly linking HNF4α, the master effector of MET, to the regulation of both de novo of DNMT 3A and 3B.
Cicchini, C., de Nonno, V., Battistelli, C., Cozzolino, A., De Santis Puzzonia, M., Ciafre', S.a., et al. (2015). Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29. BIOCHIMICA ET BIOPHYSICA ACTA. GENE REGULATORY MECHANISMS, 1849(8), 919-929 [10.1016/j.bbagrm.2015.05.005].
Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29
CIAFRE', SILVIA ANNA;
2015-01-01
Abstract
Epithelial-to-mesenchymal transition (EMT) and the reverse mesenchymal-to-epithelial transition (MET) are manifestations of cellular plasticity that imply a dynamic and profound gene expression reprogramming. While a major epigenetic code controlling the coordinated regulation of a whole transcriptional profile is guaranteed by DNA methylation, DNA methyltransferase (DNMT) activities in EMT/MET dynamics are still largely unexplored. Here, we investigated the molecular mechanisms directly linking HNF4α, the master effector of MET, to the regulation of both de novo of DNMT 3A and 3B.| File | Dimensione | Formato | |
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