An ability to produce rhythmic activity is ubiquitous for locomotor pattern generation and modulation. The role that the rhythmogenesis capacity of the spinal cord plays in injured populations has become an area of interest and systematic investigation among researchers in recent years, despite its importance being long recognized by neurophysiologists and clinicians. Given that each individual interneuron, as a rule, receives a broad convergence of various supraspinal and sensory inputs and may contribute to a vast repertoire of motor actions, the importance of assessing the functional state of the spinal locomotor circuits becomes increasingly evident. Air-stepping can be used as a unique and important model for investigating human rhythmogenesis since its manifestation is largely facilitated by a reduction of external resistance. This article aims to provide a review on current issues related to the "locomotor" state and interactions between spinal and supraspinal influences on the central pattern generator (CPG) circuitry in humans, which may be important for developing gait rehabilitation strategies in individuals with spinal cord and brain injuries.

Solopova, I., Selionov, V., Sylos Labini, F., Gurfinkel, V., Lacquaniti, F., Ivanenko, Y. (2015). Tapping into rhythm generation circuitry in humans during simulated weightlessness conditions. FRONTIERS IN SYSTEMS NEUROSCIENCE, 9 [10.3389/fnsys.2015.00014].

Tapping into rhythm generation circuitry in humans during simulated weightlessness conditions

LACQUANITI, FRANCESCO;
2015-02-18

Abstract

An ability to produce rhythmic activity is ubiquitous for locomotor pattern generation and modulation. The role that the rhythmogenesis capacity of the spinal cord plays in injured populations has become an area of interest and systematic investigation among researchers in recent years, despite its importance being long recognized by neurophysiologists and clinicians. Given that each individual interneuron, as a rule, receives a broad convergence of various supraspinal and sensory inputs and may contribute to a vast repertoire of motor actions, the importance of assessing the functional state of the spinal locomotor circuits becomes increasingly evident. Air-stepping can be used as a unique and important model for investigating human rhythmogenesis since its manifestation is largely facilitated by a reduction of external resistance. This article aims to provide a review on current issues related to the "locomotor" state and interactions between spinal and supraspinal influences on the central pattern generator (CPG) circuitry in humans, which may be important for developing gait rehabilitation strategies in individuals with spinal cord and brain injuries.
18-feb-2015
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/09 - FISIOLOGIA
English
Con Impact Factor ISI
rhythmogenesis; central pattern generator; humans; locomotion; sensory input
Solopova, I., Selionov, V., Sylos Labini, F., Gurfinkel, V., Lacquaniti, F., Ivanenko, Y. (2015). Tapping into rhythm generation circuitry in humans during simulated weightlessness conditions. FRONTIERS IN SYSTEMS NEUROSCIENCE, 9 [10.3389/fnsys.2015.00014].
Solopova, I; Selionov, V; Sylos Labini, F; Gurfinkel, V; Lacquaniti, F; Ivanenko, Y
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/110607
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