The clinical application of IFN-gamma release assays (IGRAs) has recently improved the diagnosis of latent tuberculosis infection. In a multicenter study of the Tuberculosis Network European Trialsgroup (TBNET) we aimed to ascertain in routine clinical practice the accuracy of a novel assay using selected peptides encoded in the mycobacterial genomic region of difference (RD) 1 for the diagnosis of active tuberculosis in comparison with tuberculin skin test (TST), QuantiFERON-TB GOLD In-Tube (Cellestis Ltd., Carnegie, Australia) and T-SPOT.TB (Oxfordimmunotec, Abingdon, UK).

Goletti, D., Carrara, S., Stefania, C., Butera, O., Amicosante, M., Ernst, M., et al. (2008). Accuracy of immunodiagnostic tests for active tuberculosis using single and combined results: a multicenter TBNET-Study. PLOS ONE, 3(10), e3417-e3417 [10.1371/journal.pone.0003417].

Accuracy of immunodiagnostic tests for active tuberculosis using single and combined results: a multicenter TBNET-Study

AMICOSANTE, MASSIMO;
2008-01-01

Abstract

The clinical application of IFN-gamma release assays (IGRAs) has recently improved the diagnosis of latent tuberculosis infection. In a multicenter study of the Tuberculosis Network European Trialsgroup (TBNET) we aimed to ascertain in routine clinical practice the accuracy of a novel assay using selected peptides encoded in the mycobacterial genomic region of difference (RD) 1 for the diagnosis of active tuberculosis in comparison with tuberculin skin test (TST), QuantiFERON-TB GOLD In-Tube (Cellestis Ltd., Carnegie, Australia) and T-SPOT.TB (Oxfordimmunotec, Abingdon, UK).
2008
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/04 - PATOLOGIA GENERALE
English
Sensitivity and Specificity; Reproducibility of Results; Humans; Prospective Studies; Immunologic Tests; Adult; Antigens, Bacterial; Middle Aged; Tuberculosis; Tuberculin Test; Female; Male; Mycobacterium tuberculosis
Goletti, D., Carrara, S., Stefania, C., Butera, O., Amicosante, M., Ernst, M., et al. (2008). Accuracy of immunodiagnostic tests for active tuberculosis using single and combined results: a multicenter TBNET-Study. PLOS ONE, 3(10), e3417-e3417 [10.1371/journal.pone.0003417].
Goletti, D; Carrara, S; Stefania, C; Butera, O; Amicosante, M; Ernst, M; Sauzullo, I; Vullo, V; Cirillo, D; Borroni, E; Markova, R; Drenska, R; Dominguez, J; Latorre, I; Angeletti, C; Navarra, A; Petrosillo, N; Lauria, F; Ippolito, G; Migliori, G; Lange, C; Girardi, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/107051
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